Wednesday, May 22, 2013

Anthony Weiner launches bid to become NYC mayor

NEW YORK (AP) ? Anthony Weiner's run for a renaissance is officially on.

The ex-congressman whose career imploded in a rash of raunchy tweets two years ago said in a YouTube video announcement late Tuesday that he's in the New York City mayoral race. He'd said last month he was considering it.

"I made some big mistakes and I know I let a lot of people down, but I also learned some tough lessons," he said in the video. "I'm running for mayor because I've been fighting for the middle class and those struggling to make it my entire life. And I hope I get a second chance."

With that, Weiner is embarking on an audacious comeback quest, hoping to go from punch line pol whose tweeted crotch shot was emblazoned on the nation's consciousness to leader of America's biggest city.

The video appeared late Tuesday but was not linked on his website or YouTube page. A call to Weiner was not immediately returned Wednesday.

The Democrat is jumping into a crowded field for September's primary. He's arriving with some significant advantages, including a $4.8 million campaign war chest, the possibility of more than $1 million more in public matching money, polls showing him ahead of all but one other Democrat ? and no end of name recognition.

His participation makes a runoff more likely, and many political observers feel he could at least get to the second round.

But Weiner also has continued to contend with questions about his character and the scandal that sank his career just two years ago.

After a photo of a man's bulging, underwear-clad groin appeared on his Twitter account in 2011, he initially claimed his account had been hacked. After more photos emerged ? including one of him bare-chested in his congressional office ? the married congressman eventually owned up to exchanging racy messages with several women, saying he'd never met any of them. He soon resigned.

In recent interviews, he has said he shouldn't have lied but did it because he wanted to keep the truth from his then-pregnant wife, Huma Abedin, a longtime aide to former Secretary of State Hillary Rodham Clinton. She told The New York Times Magazine that she has forgiven him.

Weiner has taken a series of steps recently to rehab his image and reintroduce himself, including the lengthy magazine profile and a series of local TV interviews. He hasn't responded to interview requests from The Associated Press.

He also has released a platform of sorts, a list of ideas styled as a blueprint for helping the city's middle class thrive. He's made a point of highlighting one or more of the concepts on most days, via his newly revived Twitter presence.

The suggestions, some of them updates from a mayoral run he nearly made in 2009, range from giving every public school student a Kindle reader to using Medicaid money to create a city-run, single-payer health system for the uninsured.

Some seem to draw on his Washington experience, such as making more use of a federal cigarette-smuggling law. But others fall squarely within City Hall, including suggestions to create a "nonprofit czar" in city government and eliminate paid positions for parent coordinators in schools.

The document also opens a window on a vision of the city ? a place with "a can-do attitude, competitive spirit and aggressive nature" ? that sounds not unlike Weiner himself. He was known during his seven terms in Washington as a vigorous defender of Democratic viewpoints, unafraid to get combative whether it was on cable TV or the House floor, and as a tireless and instinctive politician.

"Anybody who underestimates Anthony Weiner's ambition is a fool. And anybody who underestimates his ability as a candidate is a fool," retired Hunter College political science professor Kenneth Sherrill said. But "we're going to see, basically, if Weiner can take hits as well as he can dish them out."

In seeking a second chance from the public, Weiner will have to overcome some voters' misgivings. In a recent NBC New York-Marist Poll, half said they wouldn't even consider him, though the survey also showed that more registered Democrats now have a favorable than unfavorable impression of him.

Weiner can expect opponents to hammer at his prior prevaricating, and he said in a recent interview on the RNN cable network that he couldn't guarantee that no more pictures or people would emerge.

And while he might welcome attention to his policies rather than his past, they also have attracted some criticism. About a dozen young people recently demonstrated outside his Manhattan apartment building to denounce his proposal to make it easier to suspend disruptive public school students; "(hash)Weiner: You ask for a second chance in (hash)NYC2013 but deny students a second chance," read one sign, using Twitter's beloved hashtag marks.

Since leaving office, Weiner has put his government experience to work as a consultant for various companies.

His Democratic opponents include City Councilman Sal Albanese; Public Advocate Bill de Blasio; Comptroller John Liu; City Council Speaker Christine Quinn; the Rev. Erick Salgado, a pastor; and former Comptroller Bill Thompson.

Republican contenders include billionaire businessman John Catsimatidis, former Metropolitan Transportation Authority Chairman Joseph Lhota and homelessness-aid organization head George McDonald. Former White House housing official Aldolfo Carrion Jr., a Democrat who recently dropped his party affiliation, is running on the Independence Party line and also interested in the Republican nomination.

___

Follow Jennifer Peltz at http://twitter.com/jennpeltz

Source: http://news.yahoo.com/anthony-weiner-launches-bid-become-nyc-mayor-061856020.html

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Sunday, May 19, 2013

Obama talks about jobs, skills and opportunity (Washington Bureau)

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AP CEO calls records seizure unconstitutional

(AP) ? The president and CEO of The Associated Press says the government's seizure of AP journalists' phone records was "unconstitutional" and already has had a chilling effect on newsgathering.

Gary Pruitt says the Justice Department's secret subpoena of reporters' phone records has made sources less willing to talk to AP journalists.

The Justice Department disclosed the seizure of two months of phone records in a letter the AP received May 10. The letter did not state a reason, but prosecutors had said they were conducting a leaks investigation into how the AP learned about an al-Qaida bomb plot in Yemen before it was made public last year. Pruitt said the AP story contradicted the government's claim at the time there was no terrorist plot.

Pruitt spoke on CBS' "Face the Nation."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-19-US-AP-Phone-Records/id-f365deab14364310949689bdb3cbdadf

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SKorea says NKorea fires 3 short-range missiles

A South Korean man watches a TV news reporting missile launch conducted by North Korea, at a Seoul Train Station in Seoul, South Korea, Saturday, May 18, 2013. North Korea fired three short-range guided missiles into its eastern waters on Saturday, a South Korean official said. It routinely tests such missiles, but the latest launches came during a period of tentative diplomacy aimed at easing tensions. The letters at a screen read " Fired three short-range guided missiles." (AP Photo/Ahn Young-joon)

A South Korean man watches a TV news reporting missile launch conducted by North Korea, at a Seoul Train Station in Seoul, South Korea, Saturday, May 18, 2013. North Korea fired three short-range guided missiles into its eastern waters on Saturday, a South Korean official said. It routinely tests such missiles, but the latest launches came during a period of tentative diplomacy aimed at easing tensions. The letters at a screen read " Fired three short-range guided missiles." (AP Photo/Ahn Young-joon)

South Koreans watch TV news showing a footage of North Korean missiles on a military parade, at a Seoul Train Station in Seoul, South Korea, Saturday, May 18, 2013. North Korea fired three short-range guided missiles into its eastern waters on Saturday, a South Korean official said. It routinely tests such missiles, but the latest launches came during a period of tentative diplomacy aimed at easing tensions. (AP Photo/Ahn Young-joon)

(AP) ? North Korea fired three short-range guided missiles into its eastern waters on Saturday, a South Korean official said. It routinely tests such missiles, but the latest launches came during a period of tentative diplomacy aimed at easing tensions.

The North fired two missiles Saturday morning and another in the afternoon, South Korean Defense Ministry spokesman Kim Min-seok said by phone. He said the North's intent was unclear. His ministry said it is watching North Korea carefully in case it conducts a provocation against South Korea.

In March, North Korea launched what appeared to be two KN-02 missiles off its east coast. Experts believe the country is trying to improve the range and accuracy of its arsenal.

North Korea recently withdrew two mid-range "Musudan" missiles believed to be capable of reaching Guam after moving them to its east coast earlier this year, U.S. officials said. The North is banned from testing ballistic missiles under U.N. Security Council resolutions.

Earlier this year, North Korea threatened nuclear strikes on Seoul and Washington because of annual U.S.-South Korean military drills and U.N. sanctions imposed over its third nuclear test in February. The drills ended late last month. This past month, the U.S. and South Korea ended another round of naval drills involving a nuclear-powered aircraft carrier off the east coast. North Korea calls such drills preparation to invade the North.

Analysts say the recent North Korean threats were partly an attempt to push Washington to agree to disarmament-for-aid talks.

This past week, Glyn Davies, the top U.S. envoy on North Korea, ended trips to South Korea, China and Japan. On Friday, an adviser to Japanese Prime Minister Shinzo Abe returned from North Korea but didn't immediately give details of his talks with officials there.

On Monday, North Korean state media showed that the country's hard-line defense minister had been replaced by a little-known army general. Outside analysts said it was part of leader Kim Jong Un's efforts to tighten his grip on the powerful military after his father Kim Jong Il died in December 2011.

The United States and Japan are participants in six-nation nuclear disarmament talks along with the Koreas, Russia and Japan. North Korea walked out of the talks in 2009 after the United Nations condemned it for a long-range rocket launch.

North Korea possesses an array of missiles. U.S. and South Korean officials do not believe the North's claim that it has developed nuclear warheads small enough to place on a missile. Last week in Washington, South Korean President Park Geun-hye and President Barack Obama warned North Korea against further nuclear provocations.

Tension between the two Koreas remains high after both sides pulled out their workers from a jointly run factory complex earlier this year. The countries remain technically at war after the 1950-53 Korean War ended in a truce instead of a peace treaty.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-05-18-NKorea-Missile/id-f57ab532701a4370a1a925e8740319ab

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Saturday, May 18, 2013

Welcome to Google Island

Welcome to Google Island
I awoke aboard a boat, just before daybreak, which was weird. The last thing I remembered was being in San Francisco?s Moscone Center, wrapping up a four-hour Google I/O keynote liveblogging session. My last recollection was of Google CEO Larry ...

Source: http://feedproxy.google.com/~r/GearFactor/~3/hBYrn6XX10Q/

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Gap Employees Will Someday Be Replaced By This T-Shirt Folding Bot

Great news for anyone who's ever felt ignored by snooty Gap employees that seem more interested in what's happening in their headsets than their customers. To celebrate its one year anniversary, ROS Industrial put together this highlight reel of its robots in action, including a bit showing this arm deftly folding a shirt.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/y7QDCbwbXac/gap-employees-will-someday-be-replaced-by-this-t-shirt-508211061

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Friday, May 17, 2013

District of Columbia considers mandatory $250K insurance for gun ...

Handguns on display during the 2013 NRA Annual Meeting on May 5, 2013 in Houston, Texas. (Photo by Justin Sullivan/Getty Images)

Handguns on display during the 2013 NRA Annual Meeting on May 5, 2013 in Houston, Texas. (Photo by Justin Sullivan/Getty Images)

The District of Columbia?s city council will consider a proposal Thursday that would require gun owners to purchase liability insurance before they can obtain a license to own a gun.

The legislation, proposed by Democratic Councilwoman Mary Cheh,?mandates prospective gun owners to purchase a $250,000 insurance policy before the city can consider their applications.

The policy would not cover damages connected to self-defense, but it would ?specifically cover any damages resulting from negligent acts, or willful acts that are not undertaken in self-defense, involving the use of the insured firearm while it is owned by the policyholder.?

While Washington, D.C., possesses some of the nation?s strictest gun-control laws, the city would become the first to?mandate gun owners to purchase insurance if the bill passes. The District bans semiautomatic rifles and large-capacity magazines, and before 2008, handguns were banned in the city before the Supreme Court struck down the prohibition of handgun possession.

Similar insurance legislation is under consideration in multiple states, but no such legislation has yet passed.

Maryland Gov. Martin O?Malley signed into law one of the nation?s toughest gun control measures Thursday. Prompted by the Sandy Hook Elementary School shooting, the legislatios bans the sale of 45 varieties of assault weapons, requires all gun buyers to undergo safety training, and requires fingerprinting to receive a handgun license.?The new law also reduces magazine capacity from 20 rounds to 10 rounds

Source: http://tv.msnbc.com/?p=140927

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AP PHOTOS: A look back at Beckham's career

AAA??May. 16, 2013?12:43 PM ET
AP PHOTOS: A look back at Beckham's career
By The Associated Press?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?By The Associated Press

FILE - In this June 25, 2006 file photo, England's David Beckham celebrates after scoring the opening goal during the Round of 16 World Cup soccer match against Ecuador in Stuttgart, Germany. Beckham says he is retiring from soccer at the end of the season. The 38-year-old Beckham recently won a league title in a fourth country with Paris Saint-Germain. He has become a global superstar since starting his career at Manchester United. (AP Photo/Matt Dunham, FIle)

FILE - In this June 25, 2006 file photo, England's David Beckham celebrates after scoring the opening goal during the Round of 16 World Cup soccer match against Ecuador in Stuttgart, Germany. Beckham says he is retiring from soccer at the end of the season. The 38-year-old Beckham recently won a league title in a fourth country with Paris Saint-Germain. He has become a global superstar since starting his career at Manchester United. (AP Photo/Matt Dunham, FIle)

FILE - This is a May 25, 1999 file photo of Manchester United's midfielder David Beckham holding the winner's cup, after his side defeated Bayern Munich in their Champions League final football match, at the Nou Camp stadium. David Beckham is retiring from soccer after the season, ending a career in which he become a global superstar since starting his career at Manchester United. The 38-year-old Englishman recently won a league title in a fourth country with Paris Saint-Germain. He said in a statement Thursday May 16, 2013 he is "thankful to PSG for giving me the opportunity to continue but I feel now is the right time to finish my career, playing at the highest level." (AP Photo/Phil Noble/PA, File) UNITED KINGDOM OUT

FILE - This is a Thursday, May 30, 2002. file photo of England's soccer star David Beckham as he talks during a press conference near the team hotel in Westin on the Japanese island of Awaji. David Beckham is retiring from soccer after the season, ending a career in which he become a global superstar since starting his career at Manchester United. The 38-year-old Englishman recently won a league title in a fourth country with Paris Saint-Germain. He said in a statement Thursday May 16, 2013 he is "thankful to PSG for giving me the opportunity to continue but I feel now is the right time to finish my career, playing at the highest level." (AP Photo/Adam Butler, File)

FILE - In this June 25, 2006 file photo, England's captain David Beckham, left, celebrates his opening goal against Ecuador in a World Cup soccer match at the Gottlieb-Daimler stadium in Stuttgart, Germany. (AP Photo/Thomas Kienzle, File)

FILE - This is a Saturday, Oct. 6, 2001 file photo of England's captain David Beckham, left, as he is congratulated by teammate Emile Heskey after scoring their second goal against Greece during their 2002 World Cup qualifying match at Old Trafford Manchester England. David Beckham is retiring from soccer after the season, ending a career in which he become a global superstar since starting his career at Manchester United. The 38-year-old Englishman recently won a league title in a fourth country with Paris Saint-Germain. He said in a statement Thursday May 16, 2013 he is "thankful to PSG for giving me the opportunity to continue but I feel now is the right time to finish my career, playing at the highest level." (AP Photo/Adam Butler, File)

David Beckham won league titles with four clubs in four countries in a long career that included a record 115 appearances for England. The soccer superstar who also became a fashion icon and a global celebrity announced Thursday that he will retire at the end of the season.

Here's a collection of photos documenting Beckham's stellar career, not to mention his many hairstyles:

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-05-16-Beckham%20Retires-Photo%20Gallery/id-6652f2059c894647aae0ed195313c760

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Tuesday, May 14, 2013

Smell-O-Vision on your smartphone: the Scentee ChatPerf (video)

Scentee ChartPerf lets you send odors by smartphone

The dubious ability to send odors to your pals just became a distinct possibility thanks to the Scentee app and hardware from a company called ChatPerf. Seen in Japan, it works by letting you load a liquid refill into the device, which is then mixed and dispersed into the air at the command of an included app. Myriad uses come to mind, but the company noted a few, like sending a smell to a friend who also has the device, perking up a yoga session, helping you wake up or making a shoot 'em up video game more lively with the smell of, say, gunpowder. It's still a prototype, but the company hopes to bring it to market with a variety of different odors, and launch it for iPhone or Android devices. Meanwhile, you can sniff it out in the video after the break.

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Source: http://www.engadget.com/2013/05/13/smell-o-vision-on-your-smartphone-the-scentee-chatperf/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Monday, May 13, 2013

Woods keeps it dry and wins Players Championship

PONTE VEDRA BEACH, Fla. (AP) ? Tiger Woods had the last word against Sergio Garcia by winning The Players Championship on Sunday.

Woods ended a weekend of words with Garcia by finding land on the final two holes for par to close with a 2-under 70. Garcia was tied for the lead as he stood on the 17th tee and stared at the island green. He hit into the water twice to make a quadruple-bogey 7, and then hit his tee shot into the water on the 18th in a stunning collapse.

Woods joined Fred Couples, Davis Love III and Steve Elkington as multiple winners on the TPC Sawgrass. It was his 78th career win on the PGA Tour. Woods was in the scoring trailer when David Lingmerth missed a long birdie putt for a playoff.

Source: http://news.yahoo.com/woods-keeps-dry-wins-players-championship-231210851.html

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Hubble tells a tale of galactic collisions

May 12, 2013 ? When we look into the distant cosmos, the great majority of the objects we see are galaxies: immense gatherings of stars, planets, gas, dust, and dark matter, showing up in all kind of shapes. A new Hubble picture registers several, but the galaxy catalogued as 2MASX J05210136-2521450 stands out at a glance due to its interesting shape.

This object is an ultraluminous infrared galaxy which emits a tremendous amount of light at infrared wavelengths. Scientists connect this to intense star formation activity, triggered by a collision between two interacting galaxies.

The merging process has left its signs: 2MASX J05210136-2521450 presents a single, bright nucleus and a spectacular outer structure that consists of a one-sided extension of the inner arms, with a tidal tail heading in the opposite direction, formed from material ripped out from the merging galaxies by gravitational forces.

The image is a combination of exposures taken by Hubble's Advanced Camera for Surveys, using near-infrared and visible light.

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The above story is reprinted from materials provided by NASA.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/CEwR6icSleA/130512145356.htm

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Rescued women happy to be home, release first statements

CLEVELAND (AP) ? The three women allegedly imprisoned and sexually abused for years inside a padlocked Cleveland house asked for privacy Sunday, saying through an attorney that while they are grateful for overwhelming support, they also need time to heal.

Amanda Berry, Gina DeJesus, and Michelle Knight remain in seclusion, releasing their first statements since they were found May 6 when Berry escaped and told a 911 dispatcher, "I'm free now."

They thanked law enforcement and said they were grateful for the support of family and the community.

"I am so happy to be home, and I want to thank everybody for all your prayers," DeJesus said in a statement read by an attorney. "I just want time now to be with my family."

The women, now in their 20s and 30s, vanished separately between 2002 and 2004. At the time, they were 14, 16 and 20 years old.

Investigators say they spent the last nine years or more inside the home of Ariel Castro where they were repeatedly raped and only allowed outside a handful of times. Castro, 52, is being held on $8 million bond. The former school bus driver was charged with four counts of kidnapping and three counts of rape.

Prosecutors said last week they may seek aggravated murder charges ? punishable by death ? for allegedly impregnating one of his captives at least five times and forcing her miscarry by starving her and punching her in the belly.

The allegations were contained in a police report that also said Berry was forced to give birth in a plastic kiddie pool inside the home. A DNA test confirmed that Castro fathered the 6-year-old girl, who escaped the house with Berry.

After nearly a decade of being away, the three women need time to reconnect with their families, said attorney Jim Wooley.

Knight, who was the first to disappear and the last of the three released from the hospital, thanked everyone for their support and good wishes in her statement.

"I am healthy, happy and safe and will reach out to family, friends and supporters in good time."

Berry added: "Thank you so much for everything you're doing and continue to do. I am so happy to be home with my family."

The attorney said none of the women will do any media interviews until the criminal case against Castro is over. He also asked that they be given privacy.

"Give them the time, the space, and the privacy so that they can continue to get stronger," Wooley said.

The Associated Press does not usually identify people who say they are victims of sexual assault, but the women's names were widely circulated by their families, friends and law enforcement authorities for years during their disappearances and after they were found.

Donations are pouring into funds set up for the women. City Councilman Brian Cummins said $50,000 has been raised with the goal of creating a trust fund for each in hopes of making them financially independent.

Castro was represented at his first court appearance Thursday by public defender Kathleen Demetz, who said she can't speak to his guilt or innocence and advised him not to give any media interviews that might jeopardize his case.

Castro's two brothers, who were initially taken into custody but released Thursday after investigators said there was no evidence against them, told CNN that they fear people still believe they had something to do with the three missing women.

Onil and Pedro Castro said they've been getting death threats even after police decided to release them. Pedro Castro said he would have turned in his brother if he had known he was involved in the women's disappearance.

"Brother or no brother," he told CNN.

Source: http://news.yahoo.com/women-rescued-cleveland-happy-home-144654384.html

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Sunday, May 12, 2013

Astronauts Replace a Pump, Hoping to Stop Leak

[unable to retrieve full-text content]Flakes of frozen ammonia coolant were spotted drifting from the left side of the space station. But astronauts cannot seem to find the leak.
    


Source: http://www.nytimes.com/2013/05/12/science/space/astronauts-replace-a-pump-hoping-to-stop-leak.html?partner=rss&emc=rss

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Cocaine vaccine passes key testing hurdle

May 10, 2013 ? Researchers at Weill Cornell Medical College have successfully tested their novel anti-cocaine vaccine in primates, bringing them closer to launching human clinical trials.

Their study, published online by the journal Neuropsychopharmacology, used a radiological technique to demonstrate that the anti-cocaine vaccine prevented the drug from reaching the brain and producing a dopamine-induced high.

"The vaccine eats up the cocaine in the blood like a little Pac-man before it can reach the brain," says the study's lead investigator, Dr. Ronald G. Crystal, chairman of the Department of Genetic Medicine at Weill Cornell Medical College.

"We believe this strategy is a win-win for those individuals, among the estimated 1.4 million cocaine users in the United States, who are committed to breaking their addiction to the drug," he says. "Even if a person who receives the anti-cocaine vaccine falls off the wagon, cocaine will have no effect."

Dr. Crystal says he expects to begin human testing of the anti-cocaine vaccine within a year.

Cocaine, a tiny molecule drug, works to produce feelings of pleasure because it blocks the recycling of dopamine -- the so-called "pleasure" neurotransmitter -- in two areas of the brain, the putamen in the forebrain and the caudate nucleus in the brain's center. When dopamine accumulates at the nerve endings, "you get this massive flooding of dopamine and that is the feel good part of the cocaine high," says Dr. Crystal.

The novel vaccine Dr. Crystal and his colleagues developed combines bits of the common cold virus with a particle that mimics the structure of cocaine. When the vaccine is injected into an animal, its body "sees" the cold virus and mounts an immune response against both the virus and the cocaine impersonator that is hooked to it. "The immune system learns to see cocaine as an intruder," says Dr. Crystal. "Once immune cells are educated to regard cocaine as the enemy, it produces antibodies, from that moment on, against cocaine the moment the drug enters the body."

In their first study in animals, the researchers injected billions of their viral concoction into laboratory mice, and found a strong immune response was generated against the vaccine. Also, when the scientists extracted the antibodies produced by the mice and put them in test tubes, it gobbled up cocaine. They also saw that mice that received both the vaccine and cocaine were much less hyperactive than untreated mice given cocaine.

Booster Shots to Dampen the Cocaine High

In this study, the researchers sought to precisely define how effective the anti-cocaine vaccine is in non-human primates, who are closer in biology to humans than mice.

They developed a tool to measure how much cocaine attached to the dopamine transporter, which picks up dopamine in the synapse between neurons and brings it out to be recycled. If cocaine is in the brain, it binds on to the transporter, effectively blocking the transporter from ferrying dopamine out of the synapse, keeping the neurotransmitter active to produce a drug high.

In the study, the researchers attached a short-lived isotope tracer to the dopamine transporter. The activity of the tracer could be seen using positron emission tomography (PET). The tool measured how much of the tracer attached to the dopamine receptor in the presence or absence of cocaine.

The PET studies showed no difference in the binding of the tracer to the dopamine transporter in vaccinated compared to unvaccinated animals if these two groups were not given cocaine. But when cocaine was given to the primates, there was a significant drop in activity of the tracer in non-vaccinated animals. That meant that without the vaccine, cocaine displaced the tracer in binding to the dopamine receptor. Previous research had shown in humans that at least 47 percent of the dopamine transporter had to be occupied by cocaine in order to produce a drug high. The researchers found, in vaccinated primates, that cocaine occupancy of the dopamine receptor was reduced to levels of less than 20 percent.

"This is a direct demonstration in a large animal, using nuclear medicine technology, that we can reduce the amount of cocaine that reaches the brain sufficiently so that it is below the threshold by which you get the high," says Dr. Crystal.

When the vaccine is studied in humans, the non-toxic dopamine transporter tracer can be used to help study its effectiveness as well, he adds.

The researchers do not know how often the vaccine needs to be administered in humans to maintain its anti-cocaine effect. One vaccine lasted 13 weeks in mice and seven weeks in non-human primates.

"An anti-cocaine vaccination will require booster shots in humans, but we don't know yet how often these booster shots will be needed," says Dr. Crystal. "I believe that for those people who desperately want to break their addiction, a series of vaccinations will help."

Co-authors of the study include Dr. Anat Maoz, Dr. Martin J. Hicks, Dr. Shankar Vallabhajosula, Michael Synan, Dr. Paresh J. Kothari, Dr. Jonathan P. Dyke, Dr. Douglas J. Ballon, Dr. Stephen M. Kaminsky, Dr. Bishnu P. De and Dr. Jonathan B. Rosenberg from Weill Cornell Medical College; Dr. Diana Martinez from Columbia University; and Dr. George F. Koob and Dr. Kim D. Janda from The Scripps Research Institute.

The study was funded by grants from the National Institute on Drug Abuse (NIDA).

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/xf7o6yg0ou0/130510150141.htm

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Saturday, May 11, 2013

21st Century Fox's First Logo Fixes What Wasn't Broken

The logo is a volatile instrument. It can do more harm than good if it?s introduced the wrong way, or with too much fanfare, or with too much self-congratulation (remember the Gap debacle?). Which might explain why the unveiling of 21st Century Fox?s first identity, yesterday afternoon, could?ve easily slipped under the radar.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/fL3sf3tdcks/21st-century-foxs-first-logo-fixes-what-wasnt-broken-499891638

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Microsoft Is Becoming Increasingly Desperate For Apple To Make iTunes For Windows 8

windows8itunes

There?s no denying that iTunes for Windows is one of the most important projects Apple has ever done. It allowed Apple to sell iPods, then iPhones, and then iPads (as well as billions of dollars worth of movies, books and music) to owners of Windows PCs at a time when the iOS ecosystem was much more tethered to the desktop than it is today.

But iTunes on Windows isn?t quite as important as it used to be, especially now that the iPad is king and Windows 8 is here, which has cratered PC sales thanks to the general confusion around its new ?Metro? UI.

Any surprise, then, that Microsoft?s having a hard time convincing Apple to update iTunes for Windows 8?

iTunes, of course, already technically works on Windows 8, but not in Windows RT, the ARM flavor of Microsoft?s latest operating system that runs on tablets like the Microsoft Surface. If you have Windows 8 on a regular machine, iTunes will work in Windows 8 desktop mode? but it?s a sub-optimal experience, and brings you screeching-and-crashing out of Windows 8?s much-ballyhooed modern Metro UI.

Yet Apple is seemingly making no steps to sizably update Windows 8, prompting Microsoft CFO Tami Reller to openly complain:

You shouldn?t expect an iTunes app on Windows 8 any time soon. iTunes is in high demand. The welcome mat has been laid out. It?s not for lack of trying.

?Not for lack of trying.? I?m sure: iTunes is apparently one of the most searched for apps in the Windows 8 store? where it can?t be found.

It?s not surprising. Mac sales are about the only PC sales these days that aren?t completely declining. Why waste time on the massive undertaking of creating a Metro iTunes app, or an ARM-based iTunes, when Apple can just ignore Windows 8 entirely in favor of the Mac? God knows that?s what PC users as a whole are doing these days.

John BrownleeJohn Brownlee is Cult of Mac's Deputy Editor. He has also written for Wired, Playboy, Boing Boing, Popular Mechanics, VentureBeat, and Gizmodo. He lives in Boston with his girlfriend and two parakeets. You can follow him here on Twitter.

(sorry, you need Javascript to see this e-mail address)| Read more posts by John Brownlee.

Source: http://www.cultofmac.com/226948/microsoft-is-becoming-increasingly-desperate-for-apple-to-make-itunes-for-windows-8/

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House speaker demands White House release Benghazi email

WASHINGTON (Reuters) - The Republican leader of the House of Representatives called on the White House on Thursday to release more information about last year's deadly attack on the U.S. mission in Benghazi, Libya, as his party kept up its pressure on the Obama administration over the incident.

House Speaker John Boehner urged the Obama administration to release an email sent by a State Department official relaying that she had told the Libyan ambassador the attack was conducted by Islamist militants.

"The State Department would not allow our committees to keep copies of this email when it was reviewed. I would call on the president to order the State Department to release this email so the American people can see it," Boehner told a news conference.

Gregory Hicks, a former top U.S. diplomat in Libya, gave a dramatic account in a congressional hearing on Wednesday of the attack that killed the U.S. ambassador and three other Americans.

The Benghazi assault shadowed President Barack Obama as he campaigned for re-election in the autumn, as Republicans accused the administration of trying to cover up details of the attack out of concern it would make him appear weak on foreign policy. Democrats in turn accuse Republicans of seeking to use the attack to score political points.

(Reporting by Patricia Zengerle; Editing by Vicki Allen)

Source: http://news.yahoo.com/house-speaker-demands-white-house-release-benghazi-email-155257649.html

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Friday, May 10, 2013

Device for portable, ultra-precise clocks and quantum sensors developed

May 9, 2013 ? In a joint project between the Universities of Strathclyde and Glasgow, Imperial College London and the National Physical Laboratory, researchers have developed a portable way to produce ultracold atoms for quantum technology and quantum information processing.

Their research has been published in the journal Nature Nanotechnology.

Many of the most accurate measurement devices, including atomic clocks, work by observing how atoms transfer between individual quantum states. The highest precision is obtained with long observation times, often using slow-moving ultracold atoms prepared in a large apparatus.

Dr Aidan Arnold, a Lecturer in Strathclyde's Department of Physics, said: "The longer the transition of atoms can be observed, the more precisely they can be measured. It is possible to shine laser light on atoms to slow them down using the Doppler effect. We can now do this in a really small device."

The researchers have developed technology which is far more compact than previous setups but can still cool and trap large numbers of atoms for use in portable devices. They pattern the surface of a semiconductor chip to form a diffraction grating, splitting a laser into many beams that cool the atoms.

Professor Ed Hinds, who directs the Centre for Cold Matter at Imperial College London, said: "These specially micro-fabricated diffraction gratings create the perfect laser beams for trapping and cooling atoms."

Portable clocks, magnetometers and accelerometers have wide-ranging applications, including navigation on earth and in space, telecomunications, geological exploration, and medical imaging.

Dr Alastair Sinclair, Principal Scientist at the National Physical Laboratory, said: "The miniaturisation of atomic sensors using these optical gratings can make an important contribution to metrology and high-precision measurement."

Professor Charlie Ironside of the School of Engineering at the University of Glasgow said: "The specialized optical diffraction gratings were co-designed by the groups in the collaboration and some of them were microfabricated in the James Watt Nanofabrication Centre at the University of Glasgow -- the work is a good example of how a team of physicists and engineers can collaborate to produce cutting edge technology."

The project was funded by the Engineering and Physical Sciences Research Council, ESA, the EU AQUTE project, the Wellcome Trust, the UK National Measurement Office, the Royal Society of Edinburgh and the Royal Society.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/RR60G0HmrrM/130509090850.htm

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Detroit debt eyed by vulture funds | Investing | Financial Post

In the past two decades, a group of specialized hedge funds have transformed corporate bankruptcies, injecting much-needed capital while at the same time drawing fire as ?vultures.?

Now these same funds may be poised to descend on another landscape: struggling cities and counties ? and no place beckons more than Detroit.

This sudden interest in the staid world of municipal debt comes as these so-called distressed funds are looking for new places to put their money. Lucrative corporate bankruptcies have dried up, thanks in part to the Federal Reserve?s policy of low interest rates.

Of course, these hedge funds may be deterred by the financial and political constraints of local governments, which must pay police and collect trash and cannot be forced into liquidation.

But despite the risks, some are already betting hundreds of millions of dollars that there are big returns in cash-strapped governments.

Monarch Alternative Capital, which played a major role in the bankruptcy of Twinkie-maker Hostess Brands Inc, and several other funds have scooped up more than US$600 million of debts of Jefferson County, Alabama, according to court records.

But nowhere is attracting more attention than Detroit.

Everyone is looking for ways into Detroit. It?s new and unique

With US$8.6 billion in long-term debt, Detroit would be comparable to the biggest corporate failures if it eventually files for bankruptcy, a major advantage for big hedge funds that are used to investing hundreds of millions of dollars at a time.

The sheer size of Detroit?s debt should make it easier for the funds to track down very large chunks of bonds, magnifying their profit potential, cutting their research and advisory costs and giving them leverage when it comes to restructuring talks.

Bill Nowling, a spokesman for the city?s emergency manager, Kevyn Orr, said the city is still assessing its approach to its financial turnaround and said he was not aware of any contact with potential hedge fund investors.

Detroit was once America?s fifth largest city and a thriving center of U.S. industry. Now, its population has plummeted to 700,000 from a peak of 1.8 million, a third live in poverty and basic services such as street lighting have broken down. Michigan Governor Rick Snyder appointed Orr, a corporate bankruptcy expert, in March to take over the city?s finances.

Even if the city does not file for bankruptcy, its debt will likely be restructured, providing an opportunity for hedge funds to make a profit.

ROADS TO DETROIT

Financial advisors, restructuring consultants and lawyers who work with the funds have told Reuters they have been fielding calls, digging through documents and even flying to Detroit as they try to pinpoint a profitable investment.

?Everyone is looking for ways into Detroit. It?s new and unique,? said Marti Kopacz, who founded Brant Point Advisors, which provides turnaround advice to municipal governments.

One of the normally secretive distressed debt fund managers confirmed the funds are circling the Motor City.

?Detroit is something we as well as other funds have looked at,? said Alan Mintz, the founder of Stone Lion Capital, which was spun out of Paul Tudor Jones?s Tudor Investment Corp.

Like Monarch, Stone Lion has bought tens of millions of dollars of Jefferson County?s debt and has also been involved in the bankruptcy of Eastman Kodak Co, among other big corporate failures.

The hedge funds? interest in municipal debt reflects the divergent fortunes of Wall Street and Main Street.

Distressed debt funds love to jump in when most bail out. But with the coffers of U.S. companies overflowing with cash, there has been a dearth of the debt defaults, bankruptcies and liquidations that such funds normally feast on.

By contrast, a small but potentially growing number of U.S. cities and towns are struggling with pay and pension obligations that they took on in the boom years. As well as Jefferson County, the California towns of Stockton and San Bernardino have recently filed for bankruptcy.

Distressed debt investing has been one of the most successful hedge fund strategies over the past decade. Funds such as Oaktree Capital Management and Appaloosa Management buy large portions of a company?s debt and use teams of top-flight lawyers and advisors to control a bankruptcy.

In the Chapter 11 of Visteon Corp, hedge funds scooped up the car part maker?s bonds at pennies on the dollar and raised US$1.6 billion to pay off the company?s secured lenders, who had expected to own the reorganized company. The hedge funds ended up controlling Visteon, notching up large profits.

WAYS TO INVEST

Hedge funds are considering various approaches when it comes to local governments, including asset sales and loans, but in the case of Detroit the bonds are the big draw.

?If Detroit?s debt goes way, way down in value they will snap it up in the market and work for solutions that might help get Detroit back on its feet,? said Lewis Feldman, who heads the public-private development practice at the law firm Goodwin Procter.

Earlier this year, a US$25 million block of Detroit?s pension certificates traded at around 66 cents on the dollar. The buyer is unknown, but Matt Fabian of the Municipal Market Advisors research firm suggested it could be a sign of hedge fund involvement.

Explaining one hypothetical strategy, Fabian estimated that hedge funds could make a great return by negotiating repayment from Detroit as low as 80 cents on the dollar on those certificates.

While that would sting investors who bought the same debt at par, it would obviously help Detroit.

?They would do good for the citizens of Detroit and their own pocket,? Feldman said.

Fabian said a discounted repayment might chip away at the long-standing belief that muni bonds, even ones issued by a bankrupt government, are always repaid at par. That could send debt prices lower, creating more distressed muni bonds for the hedge funds to buy, he said.

Mintz, of the Stone Lion hedge fund, played down Fabian?s scenario, although he said the funds would consider accepting a below-par repayment where warranted. ?Just to gratuitously offer discounts probably wouldn?t happen,? he said.

You can?t liquidate a city

EUROPEAN BANKS

Detroit may have another ingredient to attract distressed debt hedge funds: motivated sellers.

Hector Negroni, the co-chief executive of Fundamental Credit Opportunities, a fund that specializes in muni market investing, said a significant amount of Detroit?s roughly US$1.5 billion in pension certificates is held by foreign banks.

Some advisors anticipate those banks would prefer to sell their large holdings rather than slug it out in politically charged restructuring talks overseas.

A similar situation has played out in the Jefferson County bankruptcy. A unit of Britain?s Lloyds Banking Group and French bank Societe Generale have been selling warrants to the hedge funds, according to court records.

But advisors and lawyers in the municipal world warned that while there may seem to be significant opportunities in restructuring local governments, skills honed in corporate bankruptcy may not apply.

?I think it will be a period of time where the distressed investor community will come to an appreciation that these situations are so very, very different from a commercial bankruptcy,? said Kopacz, the municipal advisor.

?Everyone points to the politics but it?s even more fundamental than that. If you live in the north you have to take care of the snow and you have to have a police department and a fire department. You can?t liquidate a city.?

? Thomson Reuters 2013

Source: http://business.financialpost.com/2013/05/08/vulture-funds-circle-detroit/

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FREE Push Notifications Library(PushSharp) for Windows Phone, Windows 8 and other platforms

FREE Push Notifications Library(PushSharp) for Windows Phone, Windows 8 and other platforms

5/9/2013

Please, tell us what you think about this news by voting

by GeekChamp

PushSharp Push Notifications Library has been added to the GeekChamp Component Marketplace.

PushSharp is an open source server-side library that supports sending push notifications for many platforms

  • Windows Phone 7 / 7.5 / 8 (including FlipTile, CycleTile, and IconicTile Templates!)
  • Windows 8
  • Apple (APNS - iPhone, iPad, Mountain Lion)
  • Android (GCM/C2DM - Phones/Tablets)
  • Firefox OS (Coming soon)

.Read more

You can also follow us on Twitter: @winphonegeek for Windows Phone; @winrtgeek for Windows 8 / WinRT

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Source: http://feedproxy.google.com/~r/Windowsphonegeek/~3/au6NygpYOsI/free-push-notifications-library-pushsharp--for-windows-phone--windows-8-and-other-platforms

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